| abstract |
(57) [Summary] (Modified) [Objective] 3-Substituted-2,4,5-trihalogenobenzoic acid (5) is efficiently obtained in a short step. [Structure] In the following reaction formula, tetrahalogenophthalic anhydride (1) is reacted with a hydroxy compound to form tetrahalogenophthalic acid monoester (2), and the halogen atom in the para position to the ester group is replaced with an R 2 O group. To give 4-substituted-3,5,6-trihalogenophthalic acid-1-ester (3), which is hydrolyzed to give 4-substituted-3,5,6 -Trihalogenophthalic acid (4), and decarboxylation reaction of the compound of the general formula (5), for example 3-methoxy-2,4 5-Trifluorobenzoic acid is produced. |