| abstract |
(57) [Summary] (Modified) [Structure] One or two or more members selected from the group consisting of amides of tranexamic acid represented by the following formula and salts thereof, and one or more anionic surfactants. Two or more, A skin external preparation containing one or more surfactants having a nitrogen atom in the molecule other than an anionic surfactant. [In the formula, R 1 and R 2 are the same or different and each represents a hydrogen atom, a linear or branched alkyl group having 1 to 18 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, or R 1 and R 2 are Shows a heterocyclic group of aziridine, azetidine, pyrrolidine, piperidine, hexahydroazepine, octahydroazocine or morpholine formed together with nitrogen atom] [Effect] Transdermal absorption promotion of amide of tranexamic acid and its salt It has excellent effects, safety, and feeling of use. |