| abstract |
(57) Abstract: [configuration] Formula (1) 3'-X 1 -Y -X 2 -5 '(1) ( wherein, nucleic acids complementary X 1 and X 2 are the nucleotide sequence of the target RNA Of the general formula (2) A-LB (2) (in the formula, A has a receptor on the cell membrane surface of an animal). (Glyco) protein or polypeptide-polycation conjugate represented by (glyco) protein or polypeptide, B a polycation, and L a linker forming a covalent bond with the amino group terminals of A and B). An RNA cleaving agent consisting of a complex with. [Effect] The RNA cleaving agent of the present invention is It specifically enters cancer cells and hybridizes with RNA and mRNA as transcription products of viral RNA and viral DNA, and cleaves and inactivates them, so that it can be used as a therapeutic agent for viruses and cancer. |