| abstract |
(57) [Summary] [Object] To provide a novel endothelin receptor antagonist peptide which has low toxicity, has an excellent antagonistic effect on the endothelin receptor, and is stable in a redox reaction. ## STR1 ## Formula (I) (SEQ ID NOS: 1 and 2): (In the formula, Xaa represents Glu or Asp, n represents 0 or 1, and the bond between Lys and Xaa is α- of Lys. Or an ε-amino group and a β- or γ-carboxyl group of Xaa are amide-bonded), an endothelin receptor antagonist peptide and an acid addition salt thereof, and the endothelin receptor antagonist peptide Become, Cardiovascular, antiallergic, and renal disease drugs. |