| abstract |
(57) [Summary] [Structure] A thrombomodulin substantially free of sialic acid, a method for producing the thrombomodulin by reacting thrombomodulin with a sialidase or a dilute acid, and an anticoagulant containing the thrombomodulin. [Effect] Since the half-life in blood is remarkably shorter than that of conventional thrombomodulin, it is useful as an active ingredient of an anticoagulant used in artificial dialysis. |