| abstract |
(57) [Summary] (Modified) [Objective] To provide a useful compound having an activity as an inhibitor of H + K + ATPase enzyme and being an inhibitor of bone resorption. A substituted quinoline derivative represented by the formula [I] and a pharmaceutically acceptable salt thereof, a method for producing the same, a pharmaceutical composition containing the same, and a therapeutic agent as an inhibitor of gastric acid secretion and bone resorption Its use. [In the formula, R 1 to R 4 are hydrogen atoms, C 1-4 is alkyl, C 1-6 alkoxy, phenyl, halogen atom, C F 3 , NO 2, etc .; R 5 to R 9 are hydrogen atoms, halogen atoms, C 1-6 alkyl, C 1-6 alkoxy, CN, N H 2 , CF 3 , NO 2, etc .; R 10 is a hydrogen atom, a halogen atom, C 1-6 alkyl, C 1-6 alkoxy, OH, CH 2 OH, NH (CH 2 ) n OH (n = 0 to 4), N H 2 etc .; A is -N = N-, -CO-S-, -CH = N -; |