| abstract |
(57) [Summary] (Correction) [Constitution] The following formula I [In the formula, Het is ArR 1 R 2 , Ar is an 8- to 10-membered bicyclic aromatic ring containing 1 to 3 N atoms or its N oxide, R 1 to R 4 are hydrogen, halogen, etc., R 5 is hydrogen, C H 3 etc., R 8 is hydrogen or X 3 -R 9, R 11 is hydrogen, Lower alkyl, etc., X 4 is CH═CH, CH 2 —Y 1, etc., Y 1 is O, S, S (O) 2 or CH 2 , and Q is —CO. 2 R 15, etc., m is 0 or 1, n is 0 to 3, p is 0 to 3 And a pharmaceutical composition containing the leukotriene biosynthesis inhibitor. [Effect] The above compounds are useful as anti-asthma agents, anti-allergic agents, anti-inflammatory agents and cytoprotective agents. They are also useful in the treatment of diarrhea, hypertension, angina, platelet aggregation, cerebral convulsions, preterm birth, spontaneous abortion, dysmenorrhea, migraine. |