| abstract |
(57) [Summary] [Structure] General formula [Chemical formula 1] (In the formula, Ar is phenyl, substituted phenyl, pyridyl or substituted pyridyl, R 1 is hydrogen, halogen or lower alkyl, and R 2 is an optionally substituted alkyl, alkenyl or alkynyl having 6 to 18 carbon atoms. , R 3 and R 4 are hydrogen and optionally substituted lower alkyl, X and Y are nitrogen and the like, and Z is halogen, hydroxyl group, methanesulfonyloxy, amino and the like) or a compound thereof. salt. [Effect] Heart failure as a coronary vasodilator, cerebral vasodilator, It is useful as a therapeutic agent for inflammation, allergy, asthma, etc. as a PAF antagonist such as ischemic heart disease and cerebral circulation disorder. |