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filingDate 1992-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1995-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H07188037-A
titleOfInvention Physiological ophthalmic compound and method for producing the same
abstract (57) [Summary] [PROBLEMS] To provide a novel physiological ophthalmic formulation having substantially the same ionic component composition as the ionic components of normal human tears and containing no preservative. [Structure] Potassium ions at a concentration of 11 to 25 mmol / l, calcium ions at a concentration of 0.2 to 0.5 mmol / l, and magnesium at a concentration of 0.15 to 0.45 mmol / l. The ingredients of the formulation containing at least the ions and bicarbonate ion at a concentration of between 1 and 36 mmol / l are mixed in a suitable container and the formulation is transferred to a pressure reaction vessel where the unstable components are in equilibrium. To reach the desired equilibrium state between the gas and the unstable component, and a sufficient amount of gas that shows the equilibrium state between the gas and the unstable component is mixed for a sufficient time to form a physiological ophthalmic formulation. To manufacture.
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