| abstract |
(57) [Summary] [Structure] This substance is a polysaccharide and can be obtained by culturing fungi, especially those belonging to the genus Klebsiella. The main constituent sugars are rhamnose, galactose, glucose, mannose and glucuronic acid, which are white to light brown powders, have a molecular weight of 10 3 to 10 7 , and have an elemental analysis of C, H, N, S and the like. [Effect] This substance strongly suppresses the decrease of glycosaminoglycan constituting cartilage matrix, exhibits a chondroprotective action, and has low toxicity. Therefore, it is extremely useful for treating arthropathy such as rheumatoid arthritis, osteoarthritis, periarthritis of the shoulder, cervical-shoulder-arm syndrome, and low back pain. |