| abstract |
(57) [Summary] (Modified) [Object] To provide a substituted 6,11-ethano-6,11-dihydrobenzo [b] quinolidinium salt and a compound thereof. A compound of formula I and a pharmaceutical composition containing said compound. [Wherein, R 1 and R 7 are 1 to 4 substituents selected from hydrogen, halogen, lower alkoxy, lower alkyl and the like; R 2 is hydrogen, lower alkyl, cyano or lower alkoxycarboxy; R 3 , R 4 are hydrogen, lower alkyl, or taken together are cycloalkyl ring, lower alkylidene group; R 5 and R 6 are (substituted) phenyl, 5-membered or 6-membered monocyclic or 9-membered or 10-membered bicyclic aromatic heterocyclic group; X − is an anion and p is 0,1] Effects The compounds are useful for treating or preventing neurodegenerative diseases or neurotoxin damage. |