| abstract |
(57) Abstract: The present invention relates to tetrahydropyrimidine derivatives and pharmaceutical compositions containing them. More particularly, the present invention relates to tetrahydropyrimidine derivatives useful in protecting DNA from DNA binding agents, chemical carcinogens and radiation damage. The pharmaceutical composition of the present invention comprises 2 -Methyl-4-carboxy-5-hydroxy-3,4 5,6-Tetrahydropyrimidine [THP (A)], its salts, 5-ethers or 5-esters, and 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine [THP (B)], Alternatively, it comprises at least one tetrahydropyrimidine derivative selected from the group consisting of salts thereof and a pharmaceutically acceptable carrier. TH The use of P (A), THP (B) or a combination thereof protects the DNA of non-neoplastic tissues from damage by DNA binding agents. |