| abstract |
(57) [Summary] [Structure] An elastase inhibitor containing a compound of formula (I) or a salt thereof as an active ingredient (wherein R 2 is H, alkyl, alkoxy, alkoxymethyl, COOR 3 , CH 2 COOR). 3, CH = CH-COOR 3 , halogen, trifluoromethyl, COR 4, OCOR 4, CH 2 OCOR 4, SO 2 R 4 , OSO 2 R 4 , CONR 5 R 6 , OCONR 5 R 6 , S O 2 NR 5 R 6 , group of formula (II), NHSO 2 R 7 , nitro, O H, hydroxymethyl, guanidino, benzyloxy, Guanidinophenylthiomethyl, morpholinosulfonylphenoxymethyl, pyridyloxymethyl or (1,1 -Dioxothiazol-3-yl) carbonyl; n is 1 to 5). [Chemical 1] [Effect] It is useful for treating and / or preventing diseases (emphysema, atherosclerosis, rheumatoid arthritis, etc.) caused by elastin degradation by elastase, collagen fiber degradation and / or abnormal proteoglycan degradation. |