| abstract |
(57) [Summary] [Structure] The present invention is (1R, 4aR, 8aR) -1,2,3,4,5,6,7,8 -Perhydroisoquinoline-1-carbonyl- (L) -prolinyl- (L) -argininaldehyde and pharmaceutically acceptable salts and solvates thereof, a pharmaceutical preparation containing the compound and a thrombin inhibitor for the preparation. The present invention provides a method for use as a coagulation inhibitor and a thromboembolic disease agent. [Effect] The compound of the present invention is a strong thrombin inhibitor, and can selectively inhibit thrombin without significantly preventing the body's original ability to dissolve clots. |