abstract |
(57) [Summary] [Objective] To provide a gene encoding a new generation plasminogen activator with improved biological efficacy and preservation. A DNA having a nucleotide sequence encoding a hybrid plasminogen activator containing three or more heterologous polypeptide kringles A unit and a replicable expression vector containing it. Efficacy Compared to natural plasminogen activator, it has increased in vivo stability, increased binding affinity for fibrin, improved half-life, and is easy to handle during preparation and production. A gene encoding a hybrid plasminogen activator is obtained. |