| abstract |
(57) [Summary] [Structure] 3,4-dihydro-1-represented by the following chemical formula 1 (2-Hydroxyphenyl) -2 (1H) -quinoxalinone derivative or its alkali metal salt. [Chemical 1] (In the formula, A is oxygen, carbonyl or NR 1 , and B is NR 2 Or CR 3 R 4 and R 3 are hydrogen or the like, or form a bond with R 1 , W is an oxygen atom or a sulfur atom, X 1 and X 2 are trifluoromethyl, etc., Y 1 is hydrogen, etc., Y 2 is hydrogen, etc. , Y 3 means halogen and the like, Y 4 means hydrogen and the like, Z means hydrogen, lower alkyl, substituted lower alkyl or a group which can be converted into a hydrogen atom in vivo. However, when A is oxygen or NR 1 , B Is CR 3 R 4 and when A is carbonyl, B is NR 2 and W are oxygen atoms. [Effect] The compound of the above chemical formula 1 and the alkali metal salt thereof have a vasodilatory action and a blood pressure lowering action based on a smooth muscle relaxing action, and thus are useful as a medicine such as a cardiovascular disease therapeutic drug. |