| abstract |
(57) [Summary] (Modified) [Structure] A condensed benzeneoxyacetic acid derivative (I) having a D ring system of (i) to (iv) and a salt thereof and a drug containing the compound or a salt thereof as an active ingredient. (R 1 is a hydroxyl group, an alkoxy group, (Alkyl) amino group, amino acid residue; A is phenyl, Imidazole residue, imidazol-2-yloxy (thio), which may be substituted with phenyl-substituted alkyl etc. Residue, 2-oxoimidazole residue, pyrazole residue, An oxadiazole residue, an oxazole residue, a triazole residue, an isoxazole residue or an isothiazole residue, wherein the benzene ring in the group is alkyl or alkoxy, It may be substituted with 1 to 3 halogen, nitro and trihalomethyl; e is 3 to 5, f is 1 to 3, p is 1 to 4, q is 0 to 2, r is 1 to 4, and s is 0 to 3). [Chemical 1] [Effect] It has a PGI 2 receptor agonistic effect and is useful for the prevention and / or treatment of thrombosis, arteriosclerosis, ischemic heart disease, gastric ulcer, hypertension and the like. |