abstract |
(57) [Summary] [Object] To provide a liposome preparation which can be stored for a long period of time without causing leakage of internal encapsulated components from the liposome. [Structure] A liposome preparation comprising liposomes having a lipid multi-layer is prepared, and water is removed from the preparation without pre-freezing the preparation, and the water rehydrates the substantial part of the lipid multi-layer. A method of dehydrating liposomes, comprising the steps of removing sufficient water to be retained in the formulation until the end point is left in the formulation, and a liposome formulation produced by the method. [Effect] A liposome preparation was obtained which could be stored for a long period of time without leaking the encapsulated components inside the liposome and could be rehydrated at the time of subsequent use. |