| abstract |
(57) [Summary] [Object] To provide a liposome preparation which can be stored for a long period of time without causing leakage of internal encapsulated components from the liposome. [Structure] A step of preparing a liposome containing one or more protective sugars and removing water from the preparation, in which the sugars have a protective concentration on both the inner and outer surfaces of the liposome membrane. Where the liposome has a concentration gradient of one or more charged species across its membrane, the concentration gradient increasing the permeable membrane potential loading the ionizable bioactive agent into the liposome. A method for dehydrating liposomes, which is capable of occurring. [Effect] A liposome preparation was obtained which could be stored for a long period of time without leaking the encapsulated components inside the liposome and could be rehydrated at the time of subsequent use. |