| abstract |
(57) [Summary] [Structure] A method for preparing interferon-α by expressing it in Escherichia coli, comprising: a) interferon-α being matured by a signal sequence of a thermostable enterotoxin II (STII) gene derived from Escherichia coli. Expressing in a cell containing a vector linked to a sequence encoding human interferon-α, b) isolating the expressed interferon-α, The above method characterized by the above. [Effect] By the above method, high-purity interferon- α can be obtained economically and efficiently. |