| abstract |
(57) [Summary] [Purpose] To provide a highly safe preparation for treating gastrointestinal ulcer. [Composition] A combination therapy preparation comprising an antimicrobial substance and an anti-ulcer substance, at least one of which is combined as a gastrointestinal mucoadhesive solid formulation. [Effect] The combination therapy preparation of the present invention adheres to the mucous membrane of the digestive tract and thus has a long residence time in the digestive tract and can sustain the pharmacological activity of the medicinal component, and each medicinal effect of the antibacterial substance and the antiulcer substance. Is synergistically enhanced, the dose of medicinal components, especially antibacterial substances is extremely small, and there are few side effects. This drug is also useful as an anti-ulcer drug showing a strong anti-Helicobacter pylori activity. |