| abstract |
(57) [Summary] (Modified) [Objective] To provide a synthetic intermediate of a specific 3-substituted-2-oxindole derivative which is an inhibitor of prostaglandin H 2 synthase and the like. [Constitution] Formula: (In the formula, A 2 is H; B 1 is at the 4th position, and S is (O) p'R 16 or COOCH 3 , or B 1 is in the 5 position and is SO 2 NHCH 3 , or B 1 is in the 4 or 5 position and is CON (CH 3 ) 2 , N'is zero; p'is 1; W 3 is S Z 1 is O or S; R 12 is H, F, C The compounds and salts thereof, and R 16 is (C 1 -C 4) alkyl); l, Br, CF 3 or (C 1 -C 6) an alkyl. |