http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H07115993-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 1993-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4cad1ca402d7b593f4d43eff590113b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccd65f814b4b81476f1aea5ec7ec9681 |
| publicationDate | 1995-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H07115993-A |
| titleOfInvention | In vitro chromosomal aberration test method using hepatocytes |
| abstract | (57) [Summary] [Structure] (1) Step of separating hepatocytes from mammalian liver, (2) (a) Proliferating hepatocytes in vitro by treating the separated hepatocytes with a growth stimulant. At the same time, the step of inducing an abnormality in the chromosome present in the hepatocytes by contacting the hepatocytes with the compound being the sample, or (b) contacting the separated hepatocytes with the compound being the sample Thereby inducing an abnormality in the chromosome existing in the hepatocytes, and then proliferating the hepatocytes in vitro by treating the hepatocytes with a growth stimulating substance, (3) A method for testing chromosomal aberrations, which comprises fixing and staining, and then observing a chromosomal abnormality present in hepatocytes to detect chromosomal aberration-inducing properties of a compound as a sample in hepatocytes. . [Effect] By the method of the present invention, it becomes possible to detect the chromosomal aberration-inducing property of a compound on hepatocytes with a small labor and time. In addition, the use of expanded hepatocytes that maintain high drug metabolism activity enables highly sensitive detection. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103221822-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012045731-A1 |
| priorityDate | 1993-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 144.