| abstract |
(57) [Summary] [Purpose] A parenteral formulation suppresses hydrolysis and reduction in activity, and continuously releases a physiologically active peptide or protein over a long period of time. [Structure] A parenteral preparation is constituted by a matrix which is solid at room temperature and contains a physiologically active peptide or protein and a diester of polyglycerin and a saturated fatty acid. The molecular weight of the physiologically active peptide or protein is 200 It is 0 Dalton or more. The average degree of polymerization of polyglycerin is about 4, and saturated fatty acids include fatty acids having about 16 to 30 carbon atoms, such as palmitic acid and stearic acid. The matrix may be columnar or granular. The parenteral preparation can be used as a solid injection (implant, etc.) or suppository to be subcutaneously or intramuscularly administered, and can release a physiologically active peptide or protein for one week or more. |