| abstract |
(57) [Summary] (Modified) [Purpose] To provide an antibody production inhibitor that sufficiently suppresses the production of antibodies that cause autoimmune diseases and is highly safe, and to combine the antibody production inhibitor. By doing so, a skin external preparation for autoimmune diseases, particularly atopic dermatitis, which is highly safe and has a sufficient medicinal effect, is provided. [Structure] Inhibiting antibody production of an ester of inosine represented by the formula (1) and a higher fatty acid having an odd number of carbon atoms and an ester of deoxyinosine represented by the formula (2) and a higher fatty acid having an odd number of carbon atoms As an agent, 0.1 to 10% by weight is added to the external preparation for skin. [Wherein R 1 , R 2 , R 3 , R 4 , and R 5 represent a higher acyl group having an odd number of carbon atoms or a hydrogen atom, and at least one of R 1 to R 3 or R 4 , Any one of R 5 represents the higher acyl group] |