| abstract |
(57) [Summary] (Modified) [Structure] A pharmaceutical preparation comprising the compound represented by the general formula (VI) or a pharmaceutically acceptable salt thereof, and the compound or a pharmaceutically acceptable salt thereof as an active ingredient. [Wherein, X is O or S; R 61 is C 4 -C 20 Alkyl, (substituted) aryl, benzyl and the like; R 62 is hydrogen, C 1 -C 3 alkyl, C 1 -C 2 alkoxy, —CN and the like; R 63 is hydrogen, halo or C 1-. C 3 alkyl; R 64 to R 67 are hydrogen, C 1 -C 10 alkyl, aryl, group -Z- (CH 2) p - Q, etc .; where p is an integer from 1 to 5, Z is a bond, O, NH, S, etc., and Q is --COOR 86 (R 86 is hydrogen, metal or C 1 -C 10 alkyl), 5- Tetrazolyl, etc.] [Effect] The compound of formula (VI) is valuable for the treatment of septic shock, adult respiratory distress syndrome, bronchial asthma, chronic joints, rheumatism and the like. |