| abstract |
(57) [Summary] (Modified) [Objective] Novel 1-phenyl-3-aryl-2-propyn-1-ones, use of these compounds as inhibitors of calcium uptake in leukocytes and platelets, And the manufacturing methods thereof. [Constitution] The following formula [Wherein R 1 , R 2 , and R 3 are each independently hydrogen, C 1- C 6 alkyl, C 1 -C 6 alkoxy, halogen, -N (Y 1) (Y 2) (wherein Y 1 and Y 2 are each independently hydrogen or C 1 -C 6 alkyl) or X Z - (Q) - (CH 2) n -O- (wherein Q is phenyl or naphthyl, n = 0 or 1, X = C 1 -C 6 alkoxy or -N (Y 1) (Y 2 ), z = 0, 1, 2) and Ar is the following formula And so on. ], Or a pharmaceutically acceptable salt thereof. |