| abstract |
(57) [Summary] (Modified) [Purpose] An antagonist useful for the treatment of gastrin secretion disorder, appetite regulation disorder, gastrointestinal active disorder, etc. [Structure] A benzazepine analog represented by the general formula [I] or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the benzazepine analog or a salt thereof. [Wherein R 1 is -X 12 COOR 6, -X 12 OR 6, - X 12 NR 4 R 5, -X 12 CN , etc.; R 2 is H, lower alkyl, (substituted phenyl, pyridyl; R 3 is -X 11 N H-CO-X 11 -R 7 , -NH- (CH 2) 2-3 - NH-CO-R 7, -X 11 '-NH-SO 2 - (CH 2) q -R 7, and the like; or R 4, R 5 is R 6, -NR 4 R 5 forms a 4- to 7-membered heterocycle; R 6 is H, lower alkyl, cyclolower alkyl, (substituted) phenyl; R 7 Indicates naphthyl, etc. |