| abstract |
(57) [Summary] (Correction) [Structure] 8-chloro-11- [1- [(5-Methyl-3-pyridyl) methyl] -4-piperidylidene] -6,11-dihydro-5H-benzo [5 6] Cyclohepta (1,2-b] pyridine and pharmaceutically acceptable salts and solvates thereof, a compound of formula II A compound of formula 4 by reacting with 5-methyl-3-pyridylmethyl chloride (or bromide) in the presence of a proton-removing base (e.g. triethylamine) in a suitable solvent, and a compound of formula 4; A pharmaceutical composition comprising an effective amount of the compound of formula 4 or a salt thereof. [Effect] The compound of formula 4 is a dual PAF antagonist and an antihistamine, and is useful for treating / preventing diseases associated with PAF and / or histamine, especially asthma or allergic disorders. |