| abstract |
(57) [Summary] (Modified) [Objective] To provide a selective leukotriene B 4 antagonist compound. A compound of the following formula or a pharmaceutically acceptable base addition salt thereof, a method for treating an immediate hypersensitivity state of a mammal such as asthma, which comprises administering them, and the compound or a base addition salt thereof Medicinal formulation. [In the formula, R 1 is C 1-10 alkyl, C 3-8 cycloalkyl, halogen, (C 1-4 alkyl) phenyl (in addition to halogen on the phenyl ring, C 1-4 alkoxy, CF 3 R 2 is C 1-5 alkyl, C 1-4 alkoxy, etc .; R 3 is —COOH, 5- Tetrazolyl, -CON (R 7) 2, cyclic groups such as benzene with a substituent; D is O, S; A is O, S, -CH = CH- etc; X is O, S, CO, CH 2 ; Y is O, C H 2 ; Z is a bond, C 1-10 alkylidene. ] |