abstract |
(57) [Summary] [Structure] The present invention is a human sperm membrane antigen peptide, a DNA encoding the same, a monoclonal antibody corresponding to the antigen peptide, and a contraceptive vaccine containing the antigen. [Effect] The monoclonal antibody (MAb1G12) corresponding to the antigen peptide of the present invention has human sperm immobilization action and fertilization inhibitory action, and the antigen of the present invention is an immunogen for contraceptive vaccines and an antibody in serum of infertile patients. It is useful as an immunological antigen. |