| abstract |
(57) [Summary] (Modified) [Objective] To provide a compound useful as an α 2 -adrenoceptor antagonist, particularly a selective α 2 -adrenoceptor antagonist. [Constitution] The following formula [I] [Wherein, X and Y are independently hydrogen; hydroxy; 1 to Lower alkyl having 6 carbon atoms; lower alkoxy having 1 to 6 carbon atoms; or halo, Or, when X and Y are adjacent to each other and are combined, it is methylenedioxy or ethylene-1,2-dioxy, and R is lower alkyl having 1 to 6 carbon atoms; 3 to 8 carbons. Cycloalkyl having atoms; phenyl or phenyl lower alkyl (phenyl is halo, lower alkyl having 1 to 4 carbon atoms and 1 ~ Optionally substituted with 1 or 2 substituents selected from the group consisting of lower alkoxy having 4 carbon atoms) |