| abstract |
(57) [Summary] (Corrected) [Constitution] The following formula [Wherein R is selected from hydrogen, methyl or ethyl and the dotted lines a and b are 5α hydrogen when b is present, H a represents a double bond provided that a does not exist; Z represents oxo, ═CH—R ′, etc., and R ′ represents H or alkyl. 7β-substituted-4-aza-5α-cholestane-represented by 3-one and related compounds. [Effect] It is effective against benign prostatic hyperplasia, acne, hirsutism, androgenetic alopecia, androgenetic alopecia, and prostatitis by inhibiting the compound steroid 5α-reductase. |