| abstract |
(57) [Summary] (Modified) [Structure] [In the formula, rings A and B are (The ketone functional group at the 3-position may be protected in the form of a ketal, a thioketal, a hemithioketal or an enol ether) R is a methyl group or a —CH 2 —OR 1 group, R 1 Is a hydrogen atom, an ether residue or an ester residue, R 1 is a hydrogen atom, R 2 is a hydroxy functional group at the α-position, R 3 Represents a hydrogen atom, a methyl group, etc.], which is obtained by treating the corresponding 16 (17) -derivative with a methylating agent and hydrolyzing the resulting methylated intermediate. The enol is oxidized with molecular oxygen in the presence of a suitable reducing agent to give the desired compound. [Effect] The above compound is useful as an anti-inflammatory agent. |