| abstract |
(57) [Summary] (Modified) [Objective] To provide a compound which directly or indirectly regulates LDL receptor synthesis at the chromosomal level and is useful for the treatment of hyperlipidemia. A pharmaceutical preparation comprising a compound of the following formula or a pharmaceutically acceptable salt thereof and, as an active ingredient, the compound or a pharmaceutically acceptable salt thereof. [In the formula, R 1 represents a linear C 1-4 (halo) alkyl; 2 is hydrogen or (halo) methyl; R 3 is hydrogen, C 1-6 (halo) alkyl or a group -CH 2 = (CR 6) -CR 7 , R 8 (provided that R 6 is hydrogen, halogen, C 1 to 4 (halo) alkyl, etc .; R 7 , R 8 represents hydrogen, halogen, (halo) methyl; or R 6 , R 7 may form a ring with the carbon atom to which it is attached); R 4 is hydrogen, substituted benzyl, etc .; R 5 is a group —CH (CH 3 ) — (C H 2 ) 3 —CH (CH 3 ) 2 and the like; |