| abstract |
(57) [Summary] (Modified) [Objective] To provide a novel compound effective as a 5-lipoxygease inhibitor. A pharmaceutical composition for use in a leukotriene-mediated disease, which comprises the oxime derivative shown or a pharmaceutically acceptable salt thereof, a method for producing the same, and the oxime derivative or a pharmaceutically acceptable salt thereof. . [In the formula, R 1 is H, C 1-4 alkyl or the like; R 2 , R 3 Together - (CH 2) 2 -O- ( CH 2) 2 - a divalent group such as; R 4 is H, C 1 to 4 alkyl, phenyl or the like; R 5 is H, C 1 ~ 4 alkyl, phenyl, pyridyl, furyl and the like; Ar 1 and Ar 2 are phenylenepyridindiyl, pyrimidinediyl and the like; A 1 is a direct bond or C 1-4 alkylene; A 4 is C 1-4 alkylene and the like; X 1 represents O, S (O) n (where n = 0, 1, 2; respectively) |