| abstract |
(57) [Summary] (Corrected)nObjective: Treatment of diseases responsive to lipoxygenase inhibition Of compounds for.n[Structure] The compound of general formula (I) or a pharmaceutically acceptable compound thereof The salts to be added, their production method and the compound Drug formulation.n (In the formula, for example, R is quinolyl-C 1 -C Four -Alkyl Or biaryl-C 1 -C Four -Alkyl; Z is Tylene; Y is CO or SO 2 X is oxygen Is sulfur; A is oxygen; B is an alkyl of 1 to 4 carbon atoms. Killen; R a , R 1 , R 3 And R Four Is hydrogen; and R 2 Represents amino or mono-lower alkylamino You )n[Effects] The above compounds have various inflammatory and allergic properties. Sexual symptoms such as bronchitis allergy and inflammatory disease Patients, allergic rhinitis (hay fever), eye allergies and Inflammation, inflammatory bowel disease (including Crohn's disease, ulcerative colitis Mu) and skin allergies and inflammations; and also rheumatism -Like diseases such as rheumatoid arthritis and osteoarthritis It is useful for medical treatment. |