| abstract |
(57) [Summary] (Modified) [Objective] To provide N-hydroxyurea and hydrochimic acid derivatives which inhibit the action of lipoxygenase. A compound of the general formula (I) or a pharmaceutically acceptable salt thereof, as well as a compound of the formula (I) or a pharmaceutically acceptable salt thereof, for allergic or inflammatory diseases Therapeutic drug composition. [Wherein Y is halogen, C 1-6 (halo) alkyl, C 1-6 In alkoxy or the like, n is 0, 1 to 3, but halogen and alkoxy groups cannot be bonded to the 2,3 position of indoline. R 1 is C 1-4 alkyl or amino, mono (or di) alkylamino, etc., R 4 is C 3-6 cycloalkyl, aryloxy-C 2-4 alkyl, aryl, aryl- C 1-6 alkyl and the like, A is C 1-6 alkylene, C 3-6 alkenylene, -O- (CH 2) m - ( where m = 2 ~ 4)] |