| abstract |
(57) [Summary] [Object] To provide a compound having an inhibitory action on 12-lipoxygenase, and a medicine which selectively inhibits 12-lipoxygenase. [Structure] A novel coumarin derivative and these compounds, and a coumarin derivative and a medicine containing these compounds as active ingredients. [Effect] It is possible to inhibit 12-lipoxygenase with high potency and with high selectivity, and to prevent and treat various cardiovascular diseases such as arteriosclerosis and vasospasm, and prevent metastasis of certain cancers. It is useful as a target drug, has low toxicity, and has few side effects. |