| abstract |
(57) [Summary] (Modified) [Constitution] General formula I (A is a ω-oxycarbonyldihydroxybutyl group, a tetrahydropyranyl group, a ω-oxycarbonyl-3-oxobutyl group, a formyl group or a cyano group, R 1 is a halogen atom, a substituted or unsubstituted C1-6 lower alkyl group or R 5 O- (R 5 is a lower alkyl group of which a hydrogen atom or a substituted or unsubstituted C1~6.), R 2 is a hydrogen atom or a substituted or unsubstituted lower alkyl group Cl to 6, R 3 Is a hydrogen atom or substituted or unsubstituted C1-6 And R 5 and R 2 may form a 5- or 6-membered ring together with their respective bonded oxygen atoms, and R 5 and R 3 may be 5- or 6-membered together with the bonded oxygen atom of R 5. You may form a ring. 4) a 4-fluorobiphenyl derivative. A cholesterol lowering agent or a lipid lowering agent containing the same. [Effect] The present 4-fluorobiphenyl derivative has high HM. It has a G-CoA reductase inhibitory action. |