| abstract |
(57) [Summary] (Modified) [Structure] The compound represented by formula (I), a pharmaceutically acceptable salt and solvate thereof, and the compound or a pharmaceutically acceptable salt or solvate thereof A pharmaceutical composition comprising a product as an active ingredient. [X is a single bond or -CH 2 - a; R 2 is pyrrolidino, A heterocycle selected from piperidino or hexamethyleneimino; R and R 1 are OH, —OSO 2 — (CH 2 ) n —CH 3 or —OC (═O) NH—R 3 and the like; R 3 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, (substituted) phenyl (wherein the substituents are fluoro, chloro, C 1 To C 3 alkyl or C 1 to C 3 alkoxy) Respectively; n is 3, 4 or 5 and R and R At least one of the 1 -OSO 2 - (CH 2) n - It is intended to refer to CH 3 or -OC (= O) NH-R 3. [Effect] It is useful for preventing bone loss, lowering serum cholesterol, and treating hormone-dependent breast cancer and uterine cancer. |