| abstract |
(57) [Summary] (Modified) [Structure] A compound of the general formula Ia. The compounds are useful as starting materials in the preparation of compounds of formula IIIa useful for the treatment of gastrointestinal inflammatory diseases. [In the formula, R 1a , R 2a , R 3a and R 4a are hydrogen, (chloro or fluoro) alkyl group, (chloro or fluoro) alkoxy group, halogen, CN, C F 3 , an aryl group, a benzoyl group, a cyclopropylcarbonyl group, or the like, or two adjacent groups and the carbon atom of the benzimidazole ring to which they are bonded together form a 5- to 7-membered ring. May be, R 5a , R 6a is hydrogen or an alkyl group, or together is C 3 alkylene chain to form, R 7a is hydrogen, an alkyl group, an alkoxy group, or R 8a is hydrogen or an alkyl group, or together -Z- (CH 2) p - (However, Z = O, S, CH 2 ; P = 2, 3, 4) and the like are formed] |