| abstract |
(57) [Summary] [Structure] A novel phenylsulfamide derivative represented by the following general formula (I) or a salt thereof: [Each symbol in the formula has the following meaning. [Chemical 2] X: an oxygen atom, an ethylene group (—CH 2 CH 2 —) or a vinylene group (—CH═CH—) A 1 : a carbon that may be substituted with a lower alkoxy group, a hydroxy group or a group selected from a halogen atom. Number 2 to 5 linear or branched alkylene group A 2 : single bond or vinylene group R 1 , R 2 : same or different, hydrogen atom, lower alkyl group, lower alkenyl group, lower alkynyl group, halogen 1 to 3 substituents selected from an atom, a lower alkoxy group, a cyano group, a nitro group, an amino group, a mono- or di-lower alkylamino group, a hydroxyl group, a lower alkylthio group, a trihalogenomethyl group or a carbamoyl group. [Effect] Has a TXA 2 antagonistic effect, thrombosis, angina, It is useful for bronchial asthma. |