| abstract |
(57) [Summary] (Modified) [Purpose] Human interstitial collagenase in human body fluid, human active collagenase-TIMP-1 complex in human body fluid, or human active collagenase-TIMP in human body fluid. -Providing a method for immunologically measuring the complex. [Structure] (1) Two types of monoclonal antibodies that specifically bind to human interstitial collagenase are used. (2) A monoclonal antibody that specifically binds to human interstitial collagenase and a monoclonal antibody that specifically binds to metalloproteinase inhibitor-1 (TIMP-1) are used. (3) A monoclonal antibody that specifically binds to human interstitial collagenase and a monoclonal antibody that specifically binds to metalloproteinase inhibitor-2 (TIMP-2) are used. |