| abstract |
(57) [Summary] [Object] To provide a thiadiazole derivative having an endothelin receptor antagonistic action, a cathepsin B inhibitory action, and a bone resorption inhibiting action. [Structure] General formula (I ′): [Wherein R represents a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted, and Ring A represents a pyridine ring having a substituent or an optionally substituted thiazole ring] Compounds, processes for their preparation and agents. [Effect] Endothelin receptor antagonism, cathepsin B inhibition and bone resorption inhibition. |