| abstract |
(57) [Summary] [Structure] The present invention provides certain thiopyrano [2,3,4-c, d] Indoles, methods for their preparation and methods and pharmaceutical formulations for using these compounds in mammals, especially humans. [Effects] As a leukotriene biosynthesis inhibitor, the compound of the present invention is useful as an anti-asthma, anti-allergy, anti-inflammatory and cytoprotective agent, and angina, cerebral spasm, glomerulonephritis, hepatitis, endotoxemia, psoriasis, It is also useful in the treatment of uveitis and allograft rejection and the prevention of atherosclerotic plaque formation. |