| abstract |
(57) [Abstract] [Objective] The present invention provides an activity of suppressing adipogenesis of cells, Adipocyte lipoprotein lipase (LPL) inhibitory activity, colony stimulating factor (colony s) from preadipocytes timulating factor, CSF activity of inducing the production of), activity for promoting antibody production of B cells, the activity to promote the formation of megakaryocyte colonies, activity for promoting the production of platelets, and / or hematopoietic progenitor G O phase cells Novel single polypeptide having the activity of shortening amino acid, and DNA encoding the polypeptide Etc. [Structure] That is, the present invention provides amino acid numbers 2 to 178 to 10 of the amino acid sequence shown in SEQ ID NO: 2 of the sequence listing, which is obtained by genetic engineering and does not substantially contain other proteins of human origin. A polypeptide having AGIF activity and a DNA encoding the peptide, which is composed of an amino acid sequence of up to 178. [Effect] The novel polypeptide of the present invention is expected to be used as a therapeutic drug for thrombocytopenia and other cytopenias, as an immune function enhancer, and as a preventive or therapeutic drug for morbid obesity. To be done. |