| abstract |
(57) [Summary] (Modified) [Objective] To provide a novel compound having a potent antagonistic activity of platelet activating factor (PAF). A novel pyridinium derivative represented by the formula I, a process for producing the same, and a pharmaceutical composition containing the compound. (In the formula, R 1 is C 1-6 alkyl or aryl-C. 1-6 alkyl, R 2 is aryl and Z is — O- or -NR 3 - and is, T is -O -, - NR 4 - Or a single bond, R is C 1-18 (halo) alkyl, Aryl, heteroaryl, aryl-C 1-6 alkyl or heteroaryl-C 1-6 alkyl, R 3 and R 4 are independently hydrogen, C 1-4 alkyl, aryl or C 1-4 alkylcarbonyl, and Z = When NR 3 and T = NR 4 , then R 3 and R 4 can together form a ring, or Z = NR 3 R 3 is capable of binding to R to form a ring, and W − is a counter anion) |