| abstract |
(57) [Summary] (Modified) [Objective] To provide a cyclic urea derivative having beneficial pharmacological properties, for example, an effect of suppressing platelet aggregation. [Structure] 2- (4-amidinophenyl) -4- [4- (2-Carboxy-1-propyl) phenyl] -5-methyl-4H-1,2,4-triazol-3-one, 4 -[4- (2-Carboxyethyl) phenyl] -5-methyl-2- [2- (4-piperidinyl) ethyl] -4H -1,2,4-triazol-3-one, 1- [4- (2-Carboxyethyl) phenyl] -3- [2- (4 -Piperidinyl) ethyl] -imidazolidin-2-one, 4- [4- (2-carboxy-1-pentyl) phenyl] -5-methyl-2- [2- (4-piperidinyl) Ethyl] -4H-1,2,4-triazol-3-one, and cyclic urea derivatives including their analogs, tautomers, stereoisomers and salts thereof. |