| abstract |
(57) [Summary] (Correction) [Constitution] Compound of general formula (I): [In the formula, Het is (A to D are CH or 1 or 2 of A to D is N And others represent CH; E and F are CH or N); R 1 Is C 3-6 alkyl, C 1-3 alkylthio C 1-3 alkyl; R 2 is (substituted) C 1-6 alkyl, (substituted) C 1-6 alkoxy, aryl, etc .; R 3 is H, C 1-6 alkyl, etc. And a physiologically acceptable salt and solvate thereof, a method for producing the same, and a pharmaceutical formulation for treating a disease associated with tissue degradation, which comprises the cyclic imide compound. [Effects] Inhibits metalloproteases involved in tissue degradation and causes various tissue degradation including arthrosis, cutaneous symptoms, bone resorption, inflammatory diseases, tumor invasion, multiple sclerosis and related diseases involving myelin degradation. It is useful for promoting symptoms and wound healing. |